Reading to your children has demonstrable positive effects on their brain development

August 13, 2015  |  General  |  No Comments

The beneficial effects of stimulating a child’s brain have been known for decades, at least in general terms. That is to say, children who have been regularly played with, read to, and generally interacted with by adults have a great advantage over those children who did not receive these things. The key period for this appears to be up to the age of three years. For an example of this sort of research see here, whose authors conclude:

Child development was strongly associated with socio-economic position, maternal schooling and stimulation.

General observations like this demonstrate how mental growth is entangled with the effects of socioeconomic status. Children who are economically disadvantaged encounter many problems that affect cognitive development, such as poorer nutrition, more chaotic home life, and emotional stress. Any solid information on the effect of stimulation, and of what kind, would help us sort out the relative importance of these various things. Now we some fascinating recent data about that issue.

A recent study used functional magnetic resonance imaging (fMRI) to examine just what reading to a child does to the child’s brain. The reason to examine reading in particular is that literacy and language skills correlate  with later achievement. As the investigators state:

Disparities in home cognitive environment during childhood can have dramatic impact on achievement and health. Parent-child reading has been shown to improve certain emergent literacy skills, though its effect on the brain has not yet been shown.

So a big question here is precisely what does mental stimulation, particularly reading, do to a child’s brain? Can we document what is happening between the ears? Now we have some information about that. The investigators did fMRI scans on children to identify what regions of the brain reading activated. What they found was this (from the American Academy of Pediatrics summary):

Results showed that greater home reading exposure was strongly associated with activation of specific brain areas supporting semantic processing (the extraction of meaning from language). These areas are critical for oral language and later for reading. Brain areas supporting mental imagery showed particularly strong activation, suggesting that visualization plays a key role in narrative comprehension and reading readiness, allowing children to “see” the story. This becomes increasingly important as children advance from books with pictures to books without them, where they must imagine what is going on in the text.

It is important that these observations held up even after controlling for socioeconomic status. I should note that this research is reported in what we term abstract form — the complete details are yet to be published. It also has not been confirmed (as far as I know) by other investigators yet. Even with these caveats, finding a physical locus in the brain for complicated mental events is exciting stuff.

There is a footnote to this research that goes back to the Baby Einstein controversy in 2007. If you didn’t know, the Baby Einstein products were videos whose authors claimed were educational in the sense of improving learning and brain development in infants and toddlers. The company was sued for false advertising claims and the Disney Corporation (the owner) paid out refunds to those who had bought them. More about that controversy here. Research published in 2007 actually showed regression of language in children who watched a lot of these videos. So how can we square that with the experience of reading to your child being good for the brain?

I have no data to offer about this, but I suspect the difference between putting your child in front of a TV and reading to him or her is the personal interaction that accompanies reading.

 

How placebo and nocebo effects work

July 18, 2015  |  General  |  No Comments

All physicians are familiar with what is called the placebo effect: the improvement in a patient’s symptoms after receiving a treatment that has no known effect on the particular disease. I was taught that statement could be further refined to state: improvement in a patient’s symptoms after receiving a treatment that has no known biological effect on the particular disease. The standard example is a “sugar pill.” That’s an important distinction, but it’s also clearly wrong; improvement in symptoms is obviously a biological effect, no matter the mechanism. The placebo effect is evidence of the complex interactions between mind and body because symptoms, by definition, are things perceived by the brain and cannot be specifically measured. Placebo effects are perception. They do not, for example, shrink tumors, cure asthma, or control diabetes.

The placebo effect is a key reason why, as much as possible (sometimes it isn’t), we study patient response to new treatments using a placebo arm in randomized, controlled trials. These are studies in which a patient is randomly chosen to receive either the new drug or something presumed biologically to have no effect on the particular disease. Neither the patient nor the investigator knows which one the patient is getting until after the trial is over. (Some trials compare a new treatment with an existing one — that’s a different topic.) The placebo effect is when a patient receiving the inert substance, the sugar pill, experiences an improvement. How big is the effect? Sometimes it can be as high as 30% of patients. This is why a placebo group is so important for studying disorders in which subjective symptoms are the essence of the disease, such as migraine headaches. There is no objective test one can do to assess improvement; it is all patient-reported.

How does the placebo effect work? There is a wonderful and highly understandable discussion of this in a recent edition of The New England Journal of Medicine. The article is only a couple of pages long and well worth a read. There is also a good podcast accompanying the piece. The bottom line is that clearly the placebo is not really an inert substance in the sense of doing nothing. It is doing something to the patient’s perception of symptoms, often by using known pathways of neurotransmitters in the brain. From the article:

Moreover, recent clinical research into placebo effects has provided compelling evidence that these effects are genuine biopsychosocial phenomena that represent more than simply spontaneous remission, normal symptom fluctuations, and regression to the mean.

The authors describe a fascinating example of how the placebo effect can play a role in a complex disorder like asthma. In asthma we can measure air flow as the patient breathes; that is, we can get an objective measure of how severe a patient’s problem is. The patient typically feels short of breath, and the degree of reduction of airflow correlates with that symptom. But feeling short of breath is a subjective thing. It comes from the brain. I have seen both patients in severe subjective distress with only modest reduction in airflow and patients surprisingly comfortable with very decreased objective numbers. There is a significant subjective component to asthma. This has been demonstrated by giving an placebo breathing treatment to an asthmatic and then showing that, as expected, there is no improvement in airflow. Yet the patient may experience an impressive improvement in perceived breathing symptoms.

There is also another side to the coin, what is called the nocebo effect.

 . . . the psychosocial factors that promote therapeutic placebo effects also have the potential to cause adverse consequences, known as nocebo effects. Not infrequently, patients perceive side effects of medications that are actually caused by anticipation of negative effects or heightened attentiveness to normal background discomforts of daily life in the context of a new therapeutic regimen.

Here is an example. Patients in randomized controlled trials do not know if they are receiving the placebo or not. But just in case they are receiving the real drug they are informed of possible side effects. Interestingly, 4 – 26% of patients in the placebo groups in such trials stop their participation because of these perceived adverse effects. This is the nocebo effect.

One of the most fascinating aspects of this is that there appear to be genetic predispositions among people for experiencing a placebo effect. This is an area of active research. The authors’ conclusion is a good one, I think:

Of course, placebo effects are modest as compared with the impressive results achieved by lifesaving surgery and powerful, well-targeted medications. Yet we believe such effects are at the core of what makes medicine a healing profession.

The placebo effect has always been a part of medicine. Patient’s perceptions of their physician’s compassion have long been known to be important. Really, until quite recently in medicine the placebo effect was all physicians had to offer. And it’s not a bad thing. I think it explains the modest improvements reported by some patients receiving a wide variety of what we call these days alternative therapies, such as homeopathy.

Anyway, the essay is a good review of this fascinating subject, and I recommend it to you.

Half of children may not be drinking enough water

June 30, 2015  |  General  |  No Comments

Adequate hydration, getting enough water, is vital to good health. After all, we’re mostly made of water — about 60% of our bodies is water. Our bodies are quite good at hanging on to most of this water. Our skin holds nearly all of it inside, for example. But we do lose water through what we call obligatory or insensible losses. Some is lost through our skin, such as through sweating. A fair amount is lost through our breath, since the air we breathe out is fully humidified. Our kidneys also lose water through urine. Even though these organs are very, very good at conserving water, they still need to manufacture a minimal amount of urine to keep good function. So we need to take in water every day. There is some water in food, of course, more in some foods than in others. But the bulk of our daily water needs come from drinking.

How much water do we need every day? A good general rule is that an average adult male needs around 3 liters (about 3 quarts) per day and an average adult woman requires 2.2 liters. Of course that is just the baseline. If you are doing something that increases water loss, such as moderate or severe exercise, you need additional water on top of the basal amount to make up for what you are losing. What about children? On a per weight basis children generally need more. We have some simple calculations we use to determine what we call their maintenance fluid need: 100 mL/kg for the first 10 kg of body weight, 50 mL/kg for the next 10 kg body weight, and 20 mL/kg for every kg after that until the child is adult sized. That works out to about 1 liter/day for a 10 kg (22 pound) child, 1.5 liters/day for a 20 kg (44 pound) child, and 1.9 liters for a 40 kg (88 pound) child. Again, that’s just the baseline; you need to add more for activity.

Our thirst mechanism is a key way we regulate our water, but both adults and children can take in less than their requirement but not get too thirsty if the deficit is not much. Yet that water deficit can still be significant. Chronic, mild dehydration makes you feel generally unwell, something probably all of us have experienced. For example, if you’ve been out and about most of the day and feel a bit lethargic — maybe you have a mild headache as well. Then you drink a tall glass of water and within a few minutes feel much better.

An interesting recent research study asked the question if children are, on average, as hydrated as we would recommend. They used data from the National Health and Nutrition Examination Survey, which spanned the years 2009-2012, and involved over 4,000 children between the ages of 6 – 19 years. The study was a powerful one because it didn’t just ask parents how much fluid their children drank; it measured the osmolality of the urine, which indicates how concentrated the urine is. The body normally makes urine more concentrated if it is trying to conserve water because the person isn’t drinking much.

The results were interesting. The authors found that just over half of all children were not optimally hydrated. They weren’t dehydrated, that is to say sick, but their urine osmolality was higher than what we would recommend. The authors also calculated that around 8 ounces of additional water (about 350 mL) would be sufficient to bring the average school age child up to the recommended amount. That’s the size of a standard kitchen glass of water.

The take home message for me is to offer your children plenty of water at meals and make sure they take water with them when they go to various activities, especially sports.

CBO finds that 19 million would lose their health insurance if the ACA is repealed

June 19, 2015  |  General  |  No Comments

[This is important. It was written by Phil Galewitz and republished (by permission) from Kaiser Health News (KHN), a nonprofit national health policy news service.]

Repealing the federal health law would add an additional 19 million to the ranks of the uninsured in 2016 and increase the federal deficit over the next decade, the Congressional Budget Office said Friday.

The report is the first time CBO has analyzed the costs of the health law using a format favored by congressional Republicans that factors in the effects on the overall economy. It is also the agency’s first analysis on the law under Keith Hall, the new CBO director appointed by Republicans earlier this year.

CBO projected that a repeal would increase the federal deficit by $353 billion over 10 years because of higher direct federal spending on health programs such as Medicare and lower revenues. But when including the broader effects of a repeal on the economy, including slightly higher employment, it estimated that the federal deficit would increase by $137 billion instead.

Both estimates are higher than in 2012, the last time that the CBO scored the cost of a repeal.

The latest report from the nonpartisan congressional watchdog and the Congressional Joint Committee on Taxation comes just days before the Supreme Court is expected to rule on the health law’s premium subsidies in the nearly three dozen states that rely on the federal marketplace. Such a ruling would cut off subsides to more than 6 million people and be a major blow to the Affordable Care Act. It could also boost Republican efforts to repeal the entire 2010 law, which would likely face a presidential veto.

Last week, President Barack Obama said nearly one in three uninsured Americans have been covered by the law—more than 16 million people.

The CBO said repealing the health law would first reduce the federal deficits in the next five years, but increase them steadily from 2021 through 2025. The initial savings would come from a reduction in government spending on the federal subsidies and on an expanded Medicaid program. But repealing the law would also eliminate cuts in Medicare payment rates to hospitals and other providers and new taxes on device makers and pharmaceutical companies.

The CBO projected that repeal would leave 14 million fewer people enrolled in Medicaid over the next decade. Medicaid enrollment has grown by more than 11 million since 2013, with more than half the states agreeing to expand their programs under the law.

By 2024, the number of uninsured would grow by an additional 24 million people if the law is repealed.

In 2012, the CBO projected repealing the health law would increase the federal deficit by $109 billion over 10 years.  It said the higher amount in Friday’s report reflected looking at later years when federal spending would be greater.

cbo repeal 600

 

 

 

Despite recent media spotlight there really is little controversy over the existence of shaken baby syndrome

June 1, 2015  |  General  |  No Comments

A recent series of articles in the Washington Post and a segment on NPR have caused quite a stir. The articles are about what we have called for decades “shaken baby syndrome.” It can be fatal. We now use the term non-accidental head trauma. This term replaced the older one because it is more specific; children can be deliberately harmed in other ways besides shaking. In addition, inflicted trauma can happen in other places besides the head. The Post article was about the shaking variety, and it focused on several things. It highlighted several individuals who had been apparently wrongly convicted of injuring a child through shaking. It also interviewed physicians who do not believe in the diagnostic entity; they say shaken baby syndrome does not exist. Not surprisingly the article generated a lot of comment and debate, debate that has actually been going on for some time. As a pediatric intensivist for over 30 years I have dealt with many unfortunate examples of this entity, and I have no doubt that it exists. But, like all disorders that do not have a specific, definitive test for them, deciding whether or not a child has suffered shaken baby syndrome depends upon more that some x-rays and an eye examination; you need to consider the entire context of the story.

Shaken baby syndrome was first described in the 1960s to describe the combination of several injuries: subdural hematoma (bleeding around the brain), retinal hemorrhages (bleeding at the back of the eye), and brain swelling. Rib fractures are also common because the person doing the shaking typically squeezes the child’s chest hard enough to crack ribs. How do these injuries happen with shaking? The fundamental cause is that a small baby has a relatively large head compared to the rest of his body and is unable to hold his head firmly in place because the muscles aren’t strong enough yet to do that. So shaking snaps the head back and forth, generating very large forces inside the skull as the brain bangs back and forth. This can lead to rupture of some of the small veins that surround the brain, as well as tiny vessels in the back of the eye. The brain then often swells afterwards, as any tissue does when injured. If death or severe injury follows it is generally because of the brain swelling. If ribs are broken from squeezing the chest, the fractures happen at the back of the bones where the ribs come off the spinal column. It is often illustrated in this way.

There have always been some issues about diagnosing the syndrome. The main one is that all of the components of shaken baby syndrome can occur individually in other settings. Another issue is that, as in most cases of potential child abuse, the alleged assault is unwitnessed and the victim cannot give any evidence. So all evidence is circumstantial. And, of course, the stakes are very high not just for the injured child; adult caregivers can be convicted for murder. The Post article focuses on several cases like that. Some physicians have gone as far to claim that the syndrome doesn’t even exist. The American Academy of Pediatrics vigorously disagrees:

Journalists can be commended for addressing child abuse. Unfortunately, the Post’s report is seriously unbalanced, sowing doubt on scientific issues that actually are well-established. It is very clear that shaking a baby is dangerous.

It is important to acknowledge that mistakes probably have been made in both over-diagnosing and under-diagnosing abuse. The Post focused on over-diagnosis, but under-diagnosis also is a problem, leaving babies vulnerable to further abuse and even death. It’s critical we get this right.

Well okay, you might say. Of course the Pediatric Establishment would say something like that. But I think it is clear the syndrome exists. I have seen it many times and have been involved in legal proceedings charging the perpetrator, the majority of whom ultimately confessed to the act. The thing is, in all the cases I have been involved in there were other things that pointed toward child abuse. For example, a baby’s tissues are delicate and the squeezing and shaking often causes obvious bruising. I have seen several cases where the bruises even matched adult finger marks. If rib fractures are present, there is essentially no way a baby could break ribs in the typical places without shaking. Finally, and very important, is the history. Injuries like bleeding in the brain need to be explained. If there was no child abuse, then there has to be another coherent, logical explanation. I have never been involved in a case in which the potential perpetrators (or their lawyers) could give such an explanation. I have been involved, however, in cases in which no perpetrator was identified because several were possible and none came forward with the real story. More from the AAP:

What are the facts? [about denying the existence of the syndrome] . . . it involves a tiny cadre of physicians. These few physicians testify regularly for the defense in criminal trials — even when the medical evidence indicating abuse is overwhelming. They deny what science in this field has well-established. They are well beyond the bounds where professionals may disagree reasonably. Instead, they concoct different and changing theories, ones not based on medical evidence and scientific principles. All they need to do in the courtroom is to obfuscate the science and sow doubt.

Miscarriages of justice are tragic. But so is child abuse, and it is unfortunately not uncommon. Jury trials are imprecise and blunt tools of justice. If I were sitting in the jury box, I would like some other evidence besides just the triad of subdural hematoma, retinal hemorrhages, and brain swelling. In my experience there is generally additional evidence. I think the Post article is more than a little like the way the media portrays other scientific issues — controversy sells (or these days attracts page views). The media presents several scientific issues, for example childhood vaccinations, as he-said-she-said stories even when the scientific consensus is overwhelmingly one way and not the other.

 

“Cowboy” doctors mostly increase costs and risks without benefiting patients

May 12, 2015  |  General  |  2 Comments

Some months back I read an interesting interview with Jonathan Skinner, a researcher who works with the group at the renowned Dartmouth Atlas of Health Care. More than anyone else I can think of, the people at the Dartmouth Atlas have studied and tried both to understand and to explain the amazing variations we see in how medicine is practiced in various parts of the country. It turns out that specific conditions are treated in quite different ways depending upon where you live. Atul Gawande documented a detailed example of the phenomenon in an excellent New Yorker article here. A major determinant appears to be local physician culture, how we doctors “do things here.” The disturbing observation is that patient outcomes aren’t much different, just cost. Of course it’s more than cost. Doing more things to patients also increases risk, and adding risk without benefit is not what we want to be doing.

Skinner is interested in something else, a phenomenon he calls “cowboy doctors.” By this he means physicians who are individual outliers, who go against the grain by substituting their own individual judgements for those of the majority of their peers. In theory such lone wolf practitioners could go both ways. They could do less than the norm, but almost invariably they do more — more tests, more treatments, more procedures. Such physicians not only may put their patients at higher risk, they also add to medical costs. I have met physicians like that and have usually found them to be defiant in their nonconformity. A few revel in it. They maintain they are doing it for the good of their patients, but there is more than a little of that old physician ego involved. There is also the subtext of what many physicians feel these days, especially old codgers like me who have been practicing for 35 years: it is the tension between older notions of medicine as an art, a craft, and newer evidence-based, team driven practice. Skinner describes it this way:

It’s the individual craftsman versus the member of a team. And you could say, ‘Well, but these are the pioneers.’ But they’re less likely to be board-certified; there’s no evidence that what they’re doing is leading to better outcomes. So we conclude that this is a characteristic of a profession that’s torn between the artisan, the single Marcus Welby who knows everything, versus the idea of doctors who adapt to clinical evidence and who may drop procedures that have been shown not to be effective.

Leaving aside outcomes and moving on to costs, Skinner and his colleagues were quite surprised to discover how much these self-styled cowboys and cowgirls were adding to the nation’s medical bills. They found that such physicians accounted for around 17% of the variability in regional healthcare costs. To put that in dollars, it amounts to a half-trillion dollars. That is an astounding number.

So what we are looking at here is a dichotomous explanation for the huge regional variations in medical costs. On the one hand we have physicians who conform to the local culture, stay members of the herd and go along with the group, even if the group does things in a much more expensive way that confers no additional benefit to patients. On the other hand we have self-styled mavericks who scorn the herd and believe they have special insight into what is best, even if all the research shows they’re wrong.

I think what is coming from all this cost and outcome research is that best practice, evidence-based medicine (when we have that — often we don’t for many diseases) will be enforced by the people who pay the bills and professional organizations. Yes, some will bemoan this as the loss of physician autonomy and the reduction of medical practice to cookbooks and protocols. I sympathize with that viewpoint a little, especially since I am the son and grandson of physicians whose practice experience goes back to 1903. But really, there are many things we used to do that we know now are useless or even harmful. An old professor of mine had a favorite saying for overeager residents: “Don’t just do something — stand there!”

For those who would like to dive into the data and see the actual research paper from the National Bureau of Economic Research describing all this, you can read it here.

 

Recalling a public health triumph: the eradication of cretinism

April 30, 2015  |  General  |  No Comments

One of the words we don’t use any more is cretin; it’s long been a derogatory slur rather than a precise description of something. But a century ago cretinism actually meant a specific thing: a person, generally a child, who was severely damaged by a lack of thyroid hormone during early development, particularly fetal development. Now we call the condition congenital hypothyroidism. A few cases still exist, which is why we screen all newborns for thyroid function. But the overwhelmingly most common cause a century ago was hypothyroidism — low thyroid hormone — in pregnant women. The overwhelmingly most common cause of that was deficiency of iodine in the diet.

The thyroid gland sits in the front of your neck, just below your voice box (larynx). It has two lobes on either side connected by a little bridge. Its job is to make, store, and release thyroxine, or thyroid hormone. This hormone has several important functions, acting upon nearly every cell in the body in one way or another. It affects the metabolism of cells, how they use energy, and is key to cellular growth and development. The thyroid gland needs iodine to make thyroxine properly. A thyroid that is not making thyroxine properly may swell into a goiter, another thing that once was common and now is rare. There are various reasons adults may develop low thyroxine levels, become hypothyroid. These days this condition is easily treated by taking oral thyroid hormone every day. The problem for a baby developing in the womb is that a deficiency of thyroxine in the mother causes irreversible damage before the baby is born, and thus before we can give the infant thyroid hormone.

Congenital hypothyroidism is now rare in the developed world. Why? You can read the history lesson of why in a nice review here, but the reason is iodine supplementation of food, particularly salt. This is a fascinating example of several companies, particularly the giant Morton Salt Company, listening to the advice of medical experts and then just adding iodine to their product. This turned out to be an easy thing to do.

The result was an astounding public health triumph. Congenital hypothyroidism on the basis of iodine deficiency is still a problem in the developing world, but it has been eliminated from the developed world. To me it brings to mind the addition of fluoride to water and the subsequent dramatic reduction in dental caries in children. Interestingly, although I have a graduate degree in history of medicine, I am unaware of any organized efforts by people to resist iodized salt as there has occasionally been for fluoridated water. You can buy salt without iodine, although I don’t know why you would want to, but salt is found in nearly every food product that has been processed in any way, such as bread. So you can’t really avoid it.

Again, this is an example of a simple, well targeted population intervention, like vaccination, that conquered a disease that had plagued people for millennia.

Has Obamacare made it easier or harder to get a doctor’s appointment?

April 23, 2015  |  General  |  No Comments

One of the goals of the Affordable Care Act (aka Obamacare) was to increase access to primary care physicians. The notion is that if people have insurance it would be easier for them to get appointments with primary care physicians. This is because many physicians are unwilling to accept new patients who are uninsured. Further, a key component of the ACA was to increase physician reimbursement for Medicaid because this program was a major mechanism for expanding insurance coverage. Medicaid reimbursement has always been low — significantly lower than Medicare pays for the same encounter — so many physicians would not take it. The ACA drafters hoped higher reimbursement would entice these physicians to accept Medicaid. We don’t know if any of these assumptions are correct, but a recent study published in The New England Journal of Medicine suggests a positive impact.

The authors’ method was a bit sneaky, I suppose. They had trained field staff call physicians’ offices posing as potential patients asking for new appointments. They were divided into two groups; one group said they had private insurance, the other said they had Medicaid. The authors compared two time periods — before and after the early implementation of the ACA. A sample of states were compared to see if the rates of acceptance of new Medicaid patients was associated with a particular state increasing physician Medicaid reimbursement.

The results were not striking, but they suggest a significant positive trend. This is what the results showed, in the authors’ words:

The availability of primary care appointments in the Medicaid group increased by 7.7 percentage points, from 58.7% to 66.4%, between the two time periods. The states with the largest increases in availability tended to be those with the largest increases in reimbursements, with an estimated increase of 1.25 percentage points in availability per 10% increase in Medicaid reimbursements (P=0.03). No such association was observed in the private-insurance group.

Again, these are data from the early days of ACA implementation. But they are encouraging. One of the most important components of slowing the seemingly inexorable rise in healthcare costs is getting people good primary and preventative care. This keeps people with a chronic, manageable condition out of the emergency room and, one hopes, out of the hospital. This is particularly the case with common conditions like diabetes and asthma. For both of those disorders regular care by a primary care physician can spare patients much suffering and save many thousands of dollars.

I hope this kind of research continues as the ACA matures. It’s a good way to see if the overall goals are being met. Of course it raises a new challenge: making sure we have enough primary care physicians. Right now we don’t.

Measuring the economic good of Medicaid and CHIP over the long term

April 16, 2015  |  General  |  No Comments

The CHIP program (Children’s Health Insurance Program) has just been reauthorized by Congress. This is a program that provides health insurance for children of lower income families who still make too much income to qualify for Medicaid. Both CHIP and Medicaid provide essential, even life-saving healthcare for kids. That’s a good thing. A recent research study asked a deeper question: What are the long-term economic effects of providing this care, of keeping children healthy into adulthood? Their study doesn’t address the humanitarian aspects, which are huge, but rather the cold, hard economic ones.

The authors used the expansion of Medicaid and the implementation of CHIP that occurred in the 1990s to follow children who had obtained healthcare via those programs and were now adults. The bottom line is that well over half of those healthcare dollars spent were recouped in the form of taxes over the working lifetime of the subjects. Again, this doesn’t even take into account the global benefit to society of keeping people from suffering. In the words of the authors:

The government will recoup 56 cents of each dollar spent on childhood Medicaid by the time these children reach age 60. This return on investment does not take into account other benefits that accrue directly to the children, including estimated decreases in mortality and increases in college attendance.

There were several, less measurable multiplier effects that pushed the return even higher than that. One of these was the probability of the subjects collecting Earned Income Tax Credits in the future. They conclude:

We find that by expanding Medicaid to children, the government recoups much of its investment over time in the form of higher future tax payments. Moreover, children exposed to Medicaid collect less money from the government in the form of the Earned Income Tax Credit, and the women have higher cumulative earnings by age 28. Aside from the positive return on the government investment, the eligible children themselves also experience decreases in mortality and increases in college attendance.

To me it seems pretty intuitive that keeping children healthy makes them more likely to be healthy adults, and healthy adults are more likely to become able-bodied, working taxpayers. They also have longer lifespans. This study gives important, long-term data to support that intuition. Plus, it’s the right thing to do.

Pediatric Newsletter #15: Food Allergies, Gluten, and Pizza

March 29, 2015  |  General  |  No Comments

Welcome to the latest edition of my newsletter for parents about pediatric topics. In it I highlight and comment on new research, news stories, or anything else about children’s health I think will interest parents. In this particular issue I tell you about a couple of new findings about allergies in children, as well as some new information about gluten sensitivity. I have over 30 years of experience practicing pediatrics, pediatric critical care (intensive care), and pediatric emergency room care. So sometimes I’ll use examples from that experience to make a point I think is worth talking about. If you would like to subscribe, there is a sign-up form on the home page.

Big News About Peanut Allergies

This one made a big splash both in the medical news sites and in the general media. Peanut allergy is common. It has doubled in the past decade, now affecting between 1 and 3% of all children. And it can be a big deal for children who have it, even life-threatening. For years we recommended that children not be given peanut products early in life, especially if they are at risk (based on their other medical issues) for developing allergy. Unfortunately, avoiding peanuts in the first year of life doesn’t make a child less likely to develop the allergy. So what, if anything, can?

This recent, very well done study published in the prestigious New England Journal of Medicine is really ground-breaking. It took 4 to 11-month-old children at high risk for developing peanut allergy and divided them into 2 groups. One group got the “standard” approach — being told to avoid peanut exposure. The other group was fed peanuts 3 times per week. It was done in the form of either a peanut snack or peanut butter.

At age 5 years (the long follow-up time is a particularly strong feature of the study) the children who had been fed the peanuts had nearly a 90% reduction in the development of peanut allergy. This is a huge difference.

The study also was able to provide a scientific explanation for the difference. The children fed the peanuts developed protective antibodies that cancel out the ones that provoke the allergic response.

Washing Dishes by Hand May Reduce the Risk of Food Allergies

This report comes from Pediatrics, the journal of the American Academy of Pediatrics. There has been a long-standing theory about how allergies develop in children called the “hygiene hypothesis.”

The notion is that children, particularly in Western countries, are more prone to allergies (and asthma) because their exposure to microbes is delayed by our more sanitized environment.

In this study from Sweden, children in households that washed dishes by hand rather than using a dishwasher experienced a lower risk of subsequent allergies. The authors speculated that there was a causal association. They couldn’t prove that, but they also noted that early exposure to fermented foods and if the family bought food directly from farms also correlated with less allergies. I’m not totally convinced, but it is an interesting study worth thinking about. I expect to see more on the topic.

Does the Age at Which You Introduce Gluten Into Your Child’s Diet Affect Future Risk of Gluten Sensitivity?

Gluten sensitivity is in the news, with signs everywhere advertising “gluten free” as if this is always a good thing. I hear a lot of misconceptions about gluten sensitivity. Gluten is a protein found in grains such as wheat and barley. There is a condition, called celiac disease or sprue, in which a person can develop moderate or severe intestinal symptoms triggered by gluten. It is one of the eighty or so autoimmune diseases. The incidence of celiac disease in the US is about 0.7%. The risk of developing celiac disease is closely linked to a genetic predisposition to getting it. Importantly, if you don’t have the disorder, there is no benefit to eliminating gluten from your diet. In fact, the great majority of people who think they have sensitivity to gluten . . . don’t.

But for those children who do have a higher risk for developing celiac disease because of their genetic makeup it has long been a question if delaying gluten exposure will affect their chances of actually getting the disease. A good recent study gives an answer to that question, and the answer is no. There is no correlation.

If you think your child (or you) have problems with gluten there is a useful blood test that looks for a specific antibody. However, many people who have the antibody never get symptoms of celiac disease. The ultimate test is an intestinal biopsy.

My take-away conclusion is that all this gluten-free stuff you see in, for example, restaurants, is just the latest dietary fad. For over 99% of us there is no health benefit to avoiding gluten.

So How Much Pizza Do Teenagers Eat?

This is kind of a quirky item. If nothing else, it demonstrates how weird the medical literature can be sometimes. Every parent knows kids, teenagers in particular, mostly love pizza. A recent article in Pediatrics, a fairly respected journal, used food surveys to find how much pizza kids eat and the percentage of their daily calories they get on average from pizza.

The answer? The authors claim that in 2010 21% of kids ages 12-19 reported eating pizza sometime in the past 24 hours. That number is actually down from a similar survey in 2003. What about calories? For those kids who reported eating pizza, it accounted for about 25% of their daily calories, and that hasn’t changed. The authors primly suggest that we should make pizza more nutritious. I wish them luck with that. And I’m 63 years old and still like pizza.